Dichloromethane → 3'-(2-Methoxycarbonylamino-3-methyl-butyryl)-5-(4'-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl]-biphenyl-4-yl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxylic acid methyl ester

HRID 214919Notes

Reaction equation

HRID 214919 reaction equation
[CH3:1][N:2]1[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1.[CH3:8][O:9][C:10]([NH:11][CH:12]([CH:13]([CH3:14])[CH3:15])[C:16](=[O:17])[N:18]1[CH:19]([c:23]2[nH:24][c:25](-[c:28]3[cH:29][cH:30][c:31](-[c:34]4[cH:35][cH:36][c:37](-[c:40]5[nH:41][c:42]([CH:45]6[N:46]([C:50]([CH:51]([CH:52]([CH3:53])[CH3:54])[NH:55][C:56](=[O:57])[O:58][CH3:59])=[O:60])[CH2:47][NH:48][CH2:49]6)[n:43][cH:44]5)[cH:38][cH:39]4)[cH:32][cH:33]3)[cH:26][n:27]2)[CH2:20][CH2:21][CH2:22]1)=[O:61].[Cl:62][C:63](=[O:64])[O:65][CH3:66].[Cl:67][CH2:68][Cl:69]>>[CH3:8][O:9][C:10]([NH:11][CH:12]([CH:13]([CH3:14])[CH3:15])[C:16](=[O:17])[N:18]1[CH:19]([c:23]2[nH:24][c:25](-[c:28]3[cH:29][cH:30][c:31](-[c:34]4[cH:35][cH:36][c:37](-[c:40]5[nH:41][c:42]([CH:45]6[N:46]([C:50]([CH:51]([CH:52]([CH3:53])[CH3:54])[NH:55][C:56](=[O:57])[O:58][CH3:59])=[O:60])[CH2:47][N:48]([C:63](=[O:64])[O:65][CH3:66])[CH2:49]6)[n:43][cH:44]5)[cH:38][cH:39]4)[cH:32][cH:33]3)[cH:26][n:27]2)[CH2:20][CH2:21][CH2:22]1)=[O:61]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6586Methyl chloroformateHCID 79724-MethylmorpholineHCID 66620775{1-[2-(5-{4'-[3'-(2-Methoxycarbonylamino-3-methyl-butyryl)-2',3',4',5'-tetrahydro-3H,1'H-[2,4']biimidazolyl-4-yl]-biphenyl-4-yl}-1H-imidazol-2-yl)-pyrrolidine-1-carbonyl]-2-methyl-propyl}-carbamic acid methyl ester

Product 1

HCID 666201513'-(2-Methoxycarbonylamino-3-methyl-butyryl)-5-(4'-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl]-biphenyl-4-yl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-74cd6526d37e4ee3bb34ac5f99d918e5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…