HCID 131719019, compound → HCID 131719018, compound

HRID 21496Notes

Reaction equation

HRID 21496 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@@H:2]([C:10]([N:12]1[CH2:23][CH2:22][CH2:21][C@H:13]1[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[O:11])[CH2:3][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1>C1COCC1.[Pd]>[NH2:1][C@@H:2]([C:10]([N:12]1[CH2:23][CH2:22][CH2:21][C@H:13]1[C:14]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:15])=[O:11])[CH2:3][CH:4]1[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]1

Participants

4

Reactant 1

HCID 131719019HCID 131719019, compound

Product 1

HCID 131719018HCID 131719018, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Z-DCha-Pro-OtBu (made by standard peptide coupling reactions) was hydrogenated in THF over 5% Pd-C at standard temperature and pressure for 24 h. Filtration and evaporation provided H-DCha-Pro-OtBu (oil, 100%).

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-8659f9de01c24babaeff84e03d16e14d
Source dataset
uspto-grants-1995_06
Patent number
US05424291

Reaction notes

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