Water → 1-O-tert-butyl 2-O-methyl 4-[3-fluoro-4-[5-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]pyrrolidine-1,2-dicarboxylate

HRID 2149846Notes

Reaction equation

HRID 2149846 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[F:1][c:2]1[cH:3][c:4]([C:26]2=[CH:27][CH:28]([C:38](=[O:39])[O:40][CH3:41])[N:29]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:30]2)[cH:5][cH:6][c:7]1-[c:8]1[s:9][c:10]2[n:11][c:12]([C:17]3([c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)[CH2:18][CH2:19]3)[cH:13][cH:14][c:15]2[n:16]1.[OH2:42]>>[F:1][c:2]1[cH:3][c:4]([CH:26]2[CH2:27][CH:28]([C:38](=[O:39])[O:40][CH3:41])[N:29]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:30]2)[cH:5][cH:6][c:7]1-[c:8]1[s:9][c:10]2[n:11][c:12]([C:17]3([c:20]4[cH:21][cH:22][cH:23][cH:24][cH:25]4)[CH2:18][CH2:19]3)[cH:13][cH:14][c:15]2[n:16]1

Participants

4

Reactant 3

HCID 962WaterHCID 8028TetrahydrofuranHCID 671129691-O-tert-butyl 2-O-methyl 4-[3-fluoro-4-[5-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]-2,5-dihydropyrrole-1,2-dicarboxylate

Product 1

HCID 671119231-O-tert-butyl 2-O-methyl 4-[3-fluoro-4-[5-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]pyrrolidine-1,2-dicarboxylate

Sources & evidence

ORD record
ord-433a088b56d94fa8aebe36d710606c16
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…