Methanol → 6-(Benzenesulfonyl)-8-benzyl-1-(4-fluorophenyl)-8-azabicyclo[3.2.1]octan-2-one

HRID 2149889Notes

Reaction equation

HRID 2149889 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:26]3[cH:27][cH:28][c:29]([F:32])[cH:30][cH:31]3)[C:10](=[O:25])[CH:11]=[CH:12][CH:13]1[CH:14]([S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH2:15]2.[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[CH3:39][OH:40].[OH-:41].[OH-:43].[Pd+2:42]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[C:9]2([c:26]3[cH:27][cH:28][c:29]([F:32])[cH:30][cH:31]3)[C:10](=[O:25])[CH2:11][CH2:12][CH:13]1[CH:14]([S:16](=[O:17])(=[O:18])[c:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1)[CH2:15]2

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 698917456-(Benzenesulfonyl)-8-benzyl-1-(4-fluorophenyl)-8-azabicyclo[3.2.1]oct-3-en-2-one

Product 1

HCID 696848196-(Benzenesulfonyl)-8-benzyl-1-(4-fluorophenyl)-8-azabicyclo[3.2.1]octan-2-one

Sources & evidence

ORD record
ord-f5d3489f125b4cf0ac859123ac16af9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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