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HRID2150

反应详情

EQUATION

反应方程式

HRID 2150 的结构方程式

REACTANTS

反应物

2
结构：NCCCO
HCID9086

3-Aminopropanol

C3H9NO

结构：FC(F)(F)c1cccc(Nc2nccc(-c3ccnc(Cl)c3)n2)c1
HCID19689602

未命名化合物

PRODUCTS

生成物

1
结构：OCCCNc1cc(-c2ccnc(Nc3cccc(C(F)(F)F)c3)n2)ccn1
HCID21948232

未命名化合物

PROCEDURE

实验过程

50 mg (0.143 mmol) of N-(3-trifluoromethyl-phenyl)-4-(2-chloro4-pyridyl)-2-pyrimidineamine are stirred for 44 h at 100° in 1 ml of 3-amino-1-propanol. Concentration by evaporation and chromatography (methylene chloride:methanol=9:1) give N-(3-trifluoromethyl-phenyl)-4-[2-(3-hydroxy-propyl-amino)-4-pyridyl]-2-pyrimidineamine; Rf =0.1 (methylene chloride:methanol=95:5), FAB-MS: 390, m.p. 158°-163°.

WORKUP

后处理

  1. concentrationConcentration
  2. customby evaporation and chromatography (methylene chloride:methanol=9:1)