Acetonitrile → 3-(benzyloxy)-1-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutylacetonitrile
Reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH:9]1[CH2:10][C:11](=[CH:13][C:14]#[N:15])[CH2:12]1.[CH3:49][C:50]#[N:51].[N:38]12[CH2:39][CH2:40][CH2:41][N:42]=[C:43]1[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]2.[nH:16]1[n:17][cH:18][c:19](-[c:21]2[c:22]3[c:23]([n:24][cH:25][n:26]2)[n:27]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[cH:28][cH:29]3)[cH:20]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH:9]1[CH2:10][C:11]([CH2:13][C:14]#[N:15])([n:16]2[n:17][cH:18][c:19](-[c:21]3[c:22]4[c:23]([n:24][cH:25][n:26]3)[n:27]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:36])[CH3:37])[cH:28][cH:29]4)[cH:20]2)[CH2:12]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-6c5e40e978014a6cbbf6a9f2542cb471
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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