Dichloromethane → 4-Chloro-1-(3-methoxypropyl)-2-piperidin-3-ylbenzimidazole

HRID 215075Notes

Reaction equation

HRID 215075 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([c:14]2[n:15][c:16]3[c:17]([n:18]2[CH2:19][CH2:20][CH2:21][O:22][CH3:23])[cH:24][cH:25][cH:26][c:27]3[Cl:28])[CH2:11][CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:36][CH2:37][Cl:38].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35]>>[NH:8]1[CH2:9][CH:10]([c:14]2[n:15][c:16]3[c:17]([n:18]2[CH2:19][CH2:20][CH2:21][O:22][CH3:23])[cH:24][cH:25][cH:26][c:27]3[Cl:28])[CH2:11][CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66785502Tert-butyl 3-[4-chloro-1-(3-methoxypropyl)benzimidazol-2-yl]piperidine-1-carboxylate

Product 1

HCID 667859224-Chloro-1-(3-methoxypropyl)-2-piperidin-3-ylbenzimidazole

Sources & evidence

ORD record
ord-8631ae57fbfb46ca8b81d1a67ecd3e0c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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