Dimethylformamide → 3-(4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)naphthalen-1-yl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol

HRID 2151079Notes

Reaction equation

HRID 2151079 reaction equation
[Cl:1][c:2]1[c:3]([NH:25][c:26]2[n:27][nH:28][c:29]([CH3:31])[cH:30]2)[n:4][c:5]([NH:8][c:9]2[cH:10][cH:11][c:12]([CH:19]3[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]3)[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]23)[n:6][cH:7]1.[F:32][C:33]([CH:34]1[O:35][CH2:36]1)([F:37])[F:38].[O:39]=[CH:40][N:41]([CH3:42])[CH3:43]>>[Cl:1][c:2]1[c:3]([NH:25][c:26]2[n:27][nH:28][c:29]([CH3:31])[cH:30]2)[n:4][c:5]([NH:8][c:9]2[cH:10][cH:11][c:12]([CH:19]3[CH2:20][CH2:21][N:22]([CH2:36][CH:34]([C:33]([F:32])([F:37])[F:38])[OH:35])[CH2:23][CH2:24]3)[c:13]3[cH:14][cH:15][cH:16][cH:17][c:18]23)[n:6][cH:7]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 5207692-(Trifluoromethyl)oxiraneHCID 582571215-chloro-N4-(5-methyl-1H-pyrazol-3-yl)-N2-(4-(piperidin-4-yl)naphthalene-1-yl)pyrimidine-2,4-diamine

Product 1

HCID 582571233-(4-(4-(5-chloro-4-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylamino)naphthalen-1-yl)piperidin-1-yl)-1,1,1-trifluoropropan-2-ol

Sources & evidence

ORD record
ord-f1e49598357e434286afb7f04c34e765
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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