Tetrahydrofuran → 3-[[2,6-Dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-1-(4-hydroxycyclohexyl)pyrrolidin-2-one

HRID 2151166Notes

Reaction equation

HRID 2151166 reaction equation
[CH2:52]([N+:53]([CH2:54][CH2:55][CH2:56][CH3:57])([CH2:58][CH2:59][CH2:60][CH3:61])[CH2:62][CH2:63][CH2:64][CH3:65])[CH2:66][CH2:67][CH3:68].[CH2:69]1[O:70][CH2:71][CH2:72][CH2:73]1.[Cl:1][c:2]1[cH:3][c:4](-[c:33]2[cH:34][cH:35][c:36]([C:39](=[O:40])[N:41]3[CH2:42][CH2:43][CH:44]([C:47]([F:48])([F:49])[F:50])[CH2:45][CH2:46]3)[cH:37][cH:38]2)[cH:5][c:6]([Cl:32])[c:7]1[CH2:8][CH:9]1[C:10](=[O:31])[N:11]([CH:14]2[CH2:15][CH2:16][CH:17]([O:20][Si:21]([CH:22]([CH3:23])[CH3:24])([CH:25]([CH3:26])[CH3:27])[CH:28]([CH3:29])[CH3:30])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1.[F-:51]>>[Cl:1][c:2]1[cH:3][c:4](-[c:33]2[cH:34][cH:35][c:36]([C:39](=[O:40])[N:41]3[CH2:42][CH2:43][CH:44]([C:47]([F:48])([F:49])[F:50])[CH2:45][CH2:46]3)[cH:37][cH:38]2)[cH:5][c:6]([Cl:32])[c:7]1[CH2:8][CH:9]1[C:10](=[O:31])[N:11]([CH:14]2[CH2:15][CH2:16][CH:17]([OH:20])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 66621746HCID 66621746, compound

Product 1

HCID 666217383-[[2,6-Dichloro-4-[4-[4-(trifluoromethyl)piperidine-1-carbonyl]phenyl]phenyl]methyl]-1-(4-hydroxycyclohexyl)pyrrolidin-2-one

Sources & evidence

ORD record
ord-b8f85032ed96479bb7ddb11c625a9ecb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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