Ethyl Acetate → 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

HRID 2151543Notes

Reaction equation

HRID 2151543 reaction equation
[C:17]([Cl:18])(=[O:19])[C:20]([CH3:21])([CH3:22])[CH3:23].[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([C:10](=[O:11])[OH:12])[CH2:13][CH:14]([OH:15])[CH2:16]1.[CH2:24]([CH3:25])[O:26][C:27](=[O:28])[C:29]1([NH2:34])[CH:30]([CH:32]=[CH2:33])[CH2:31]1.[CH3:35][CH2:36][O:37][C:38]([CH3:39])=[O:40]>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([C:10](=[O:12])[NH:34][C:29]2([C:27]([O:26][CH2:24][CH3:25])=[O:28])[CH:30]([CH:32]=[CH2:33])[CH2:31]2)[CH2:13][CH:14]([OH:15])[CH2:16]1

Participants

5

Reactant 4

HCID 8857Ethyl AcetateHCID 62493Pivaloyl chlorideHCID 3352551-((Tert-butoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acidHCID 22082824Ethyl 1-amino-2-vinylcyclopropanecarboxylate

Product 1

HCID 235716032-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-41934d21b66741c190aa42512a475917
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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