Dimethylformamide → 4-Chloro-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one

HRID 2152265Notes

Reaction equation

HRID 2152265 reaction equation
[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([S:8]([CH3:9])=[O:10])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[c:12](=[O:15])[cH:13][cH:14]2.[Cl:30][CH2:31][Cl:32].[NH2:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([NH:24][CH:25]([CH2:26][OH:27])[CH2:28][OH:29])[n:7]1)[n:11](-[c:16]1[c:17]([F:23])[cH:18][cH:19][cH:20][c:21]1[F:22])[c:12](=[O:15])[cH:13][cH:14]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 68294SerinolHCID 119515144-chloro-8-(2,6-difluorophenyl)-2-(methylsulfinyl)pyrido[2,3-d]pyrimidin-7(8H)-one

Product 1

HCID 119515174-Chloro-2-(2-hydroxy-1-hydroxymethyl-ethylamino)-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one

Sources & evidence

ORD record
ord-8d0c244f32574025b6e1ef5d0fe34060
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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