Hydrochloric Acid → 2,2,2-Trifluoro-N-[3-(3-{2-[(3-fluorophenyl)amino]-4-pyrimidinyl}pyrazolo-[1,5-a]pyridin-2-yl)phenyl]acetamide

HRID 2153290Notes

Reaction equation

HRID 2153290 reaction equation
[CH3:39][N:40]1[CH2:41][CH2:42][c:43]2[c:44]([cH:45][c:46]([NH:47][c:48]3[n:49][c:50](-[c:51]4[c:52](-[c:53]5[cH:54][c:55]([NH:56][C:57](=[O:58])[CH2:59][c:60]6[s:61][cH:62][cH:63][cH:64]6)[cH:65][cH:66][cH:67]5)[n:68][n:69]5[cH:70][cH:71][cH:72][cH:73][c:74]45)[cH:75][cH:76][n:77]3)[cH:78][cH:79]2)[CH2:80]1.[CH3:81][CH2:82][OH:83].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[cH:18][c:19]([NH:23][C:24]([C:25]([F:26])([F:27])[F:28])=[O:29])[cH:20][cH:21][cH:22]3)[n:10][n:11]3[c:12]2[cH:13][cH:14][cH:15][cH:16]3)[n:7]1.[ClH:38].[NH2:30][c:31]1[cH:32][cH:33][cH:34][c:35]([F:36])[cH:37]1>>[c:2]1([NH:30][c:31]2[cH:32][cH:33][cH:34][c:35]([F:36])[cH:37]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[cH:18][c:19]([NH:23][C:24]([C:25]([F:26])([F:27])[F:28])=[O:29])[cH:20][cH:21][cH:22]3)[n:10][n:11]3[c:12]2[cH:13][cH:14][cH:15][cH:16]3)[n:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 97423-FluoroanilineHCID 16749888N-[3-(3-{2-[(2-Methyl-1,2,3,4-tetrahydro-7-isoquinolinyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2-(2-thienyl)acetamideHCID 59513717N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide

Product 1

HCID 595138292,2,2-Trifluoro-N-[3-(3-{2-[(3-fluorophenyl)amino]-4-pyrimidinyl}pyrazolo-[1,5-a]pyridin-2-yl)phenyl]acetamide

Sources & evidence

ORD record
ord-2e95b52c14b145ffa48087feacaa4f1f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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