Thionyl Chloride → 2,6-difluoro-N-(thiophen-2-ylmethyl)-nicotinamide
Reaction equation
[F:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([F:11])[n:10]1.[S:19]([Cl:20])([Cl:21])=[O:22].[s:12]1[c:13]([CH2:17][NH2:18])[cH:14][cH:15][cH:16]1>>[F:1][c:2]1[c:3]([C:4](=[O:6])[NH:18][CH2:17][c:13]2[s:12][cH:16][cH:15][cH:14]2)[cH:7][cH:8][c:9]([F:11])[n:10]1Participants
4
Sources & evidence
- ORD record
- ord-777b5652992b4fa8bbbc3785043ebc1b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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