Hydrochloric Acid → {3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-hydroxy-methyl]-2,4-difluoro-phenyl}-carbamic acid benzyl ester
Reaction equation
[CH2:13]([c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[O:20][C:21]([NH:22][c:23]1[c:24]([F:32])[c:25]([CH:30]=[O:31])[c:26]([F:29])[cH:27][cH:28]1)=[O:33].[CH3:35][OH:36].[Cl:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][cH:10]2.[ClH:34].[K+:12].[OH-:11]>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[CH:30]([c:25]1[c:24]([F:32])[c:23]([NH:22][C:21]([O:20][CH2:13][c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)=[O:33])[cH:28][cH:27][c:26]1[F:29])[OH:31]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-c07d4b347ddd4027a4b889dbd9465d57
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
Loading…