Water → 2-[(t-Butyldimethylsilyloxy)methyl]-4-[(2,5-difluorophenyl)hydroxymethyl]-5-methylpyridine
Reaction equation
[Br:12][c:13]1[cH:14][c:15]([CH2:20][O:21][Si:22]([CH3:23])([CH3:24])[C:25]([CH3:26])([CH3:27])[CH3:28])[n:16][cH:17][c:18]1[CH3:19].[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH3:40][CH2:41][O:42][CH2:43][CH3:44].[CH3:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[F:29][c:30]1[c:31]([CH:32]=[O:33])[cH:34][c:35]([F:38])[cH:36][cH:37]1.[OH2:39]>>[c:13]1([CH:32]([c:31]2[c:30]([F:29])[cH:37][cH:36][c:35]([F:38])[cH:34]2)[OH:33])[cH:14][c:15]([CH2:20][O:21][Si:22]([CH3:23])([CH3:24])[C:25]([CH3:26])([CH3:27])[CH3:28])[n:16][cH:17][c:18]1[CH3:19]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-b31f4e4863ed4f2ba41b4aacdfe8c051
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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