Water → 5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one

HRID 2155845Notes

Reaction equation

HRID 2155845 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[c:15](=[O:24])[nH:16][c:17]3[c:18]2[cH:19][cH:20][c:21]([Cl:23])[cH:22]3)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:33][CH2:34][Cl:35].[F:26][C:27]([F:28])([F:29])[C:30]([OH:31])=[O:32].[OH2:25]>>[NH:8]1[CH2:9][CH2:10][CH:11]([n:14]2[c:15](=[O:24])[nH:16][c:17]3[c:18]2[cH:19][cH:20][c:21]([Cl:23])[cH:22]3)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 962WaterHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66652167tert-butyl 4-(5-chloro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 1046075-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one

Sources & evidence

ORD record
ord-366111427cb142cf814efcd4ece6dac7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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