Tetrahydrofuran → 3,5-Difluoro-2-methylamino-4-(4-trifluoromethyl-piperidin-1-yl)aniline
Reaction equation
[CH2:24]1[O:25][CH2:26][CH2:27][CH2:28]1.[F:1][c:2]1[c:3]([NH:4][CH3:5])[c:6]([N+:21]([O-:22])=[O:23])[cH:7][c:8]([F:20])[c:9]1[N:10]1[CH2:11][CH2:12][CH:13]([C:16]([F:17])([F:18])[F:19])[CH2:14][CH2:15]1>>[F:1][c:2]1[c:3]([NH:4][CH3:5])[c:6]([NH2:21])[cH:7][c:8]([F:20])[c:9]1[N:10]1[CH2:11][CH2:12][CH:13]([C:16]([F:17])([F:18])[F:19])[CH2:14][CH2:15]1Participants
3
Sources & evidence
- ORD record
- ord-05315147242e4db4b31223cb9e26bb3e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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