Dichloromethane → 7-(Cyclopropylamino)-5-(2-fluoropyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde

HRID 2156557Notes

Reaction equation

HRID 2156557 reaction equation
[CH2:37]([Cl:38])[Cl:39].[CH:1]1([N:4]([C:5](=[O:6])[O:7][C:8]([CH3:9])([CH3:10])[CH3:11])[c:12]2[cH:13][c:14](-[c:23]3[cH:24][c:25]([F:29])[n:26][cH:27][cH:28]3)[n:15][c:16]3[n:17]2[n:18][cH:19][c:20]3[CH:21]=[O:22])[CH2:2][CH2:3]1.[F:30][C:31]([F:32])([F:33])[C:34]([OH:35])=[O:36]>>[CH:1]1([NH:4][c:12]2[cH:13][c:14](-[c:23]3[cH:24][c:25]([F:29])[n:26][cH:27][cH:28]3)[n:15][c:16]3[n:17]2[n:18][cH:19][c:20]3[CH:21]=[O:22])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58314259Tert-butyl cyclopropyl(5-(2-fluoropyridin-4-yl)-3-formylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Product 1

HCID 583144727-(Cyclopropylamino)-5-(2-fluoropyridin-4-yl)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde

Sources & evidence

ORD record
ord-8901fc7c29d2490fabf63f2a9e7c890b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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