Dichloromethane → 5-(2-Benzyl-2H-indazol-6-yl)-7-pyrrolidin-3-ylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine

HRID 2157147Notes

Reaction equation

HRID 2157147 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([CH2:13][c:14]2[cH:15][c:16](-[c:24]3[cH:25][cH:26][c:27]4[cH:28][n:29]([CH2:33][c:34]5[cH:35][cH:36][cH:37][cH:38][cH:39]5)[n:30][c:31]4[cH:32]3)[c:17]3[c:18]([NH2:23])[n:19][cH:20][n:21][n:22]23)[CH2:11][CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:47][CH2:48][Cl:49].[F:40][C:41]([F:42])([F:43])[C:44]([OH:45])=[O:46]>>[NH:8]1[CH2:9][CH:10]([CH2:13][c:14]2[cH:15][c:16](-[c:24]3[cH:25][cH:26][c:27]4[cH:28][n:29]([CH2:33][c:34]5[cH:35][cH:36][cH:37][cH:38][cH:39]5)[n:30][c:31]4[cH:32]3)[c:17]3[c:18]([NH2:23])[n:19][cH:20][n:21][n:22]23)[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 585297003-[4-Amino-5-(2-benzyl-2H-indazol-6-yl)-pyrrolo[2,1-f][1,2,4]triazin-7-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 585294185-(2-Benzyl-2H-indazol-6-yl)-7-pyrrolidin-3-ylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine

Sources & evidence

ORD record
ord-0c912ac3ab3f4253b63daecaf1e5a270
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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