Citric Acid → Phthalylglycine aldehyde

HRID 2157798Notes

Reaction equation

HRID 2157798 reaction equation
[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[CH2:20][CH3:21].[CH3:45][S:46]([CH3:47])=[O:48].[Cl:49][CH2:50][Cl:51].[OH:1][CH2:2][CH2:3][N:4]1[C:5](=[O:14])[c:6]2[c:7]([cH:10][cH:11][cH:12][cH:13]2)[C:8]1=[O:9].[OH:32][C:33]([CH2:34][C:35]([C:36](=[O:37])[OH:38])([CH2:39][C:40](=[O:41])[OH:42])[OH:43])=[O:44].[S:22](=[O:23])(=[O:24])=[O:25].[n:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>>[O:1]=[CH:2][CH2:3][N:4]1[C:5](=[O:14])[c:6]2[c:7]([cH:10][cH:11][cH:12][cH:13]2)[C:8]1=[O:9]

Participants

8

Reactant 7

HCID 311Citric AcidHCID 679Dimethyl SulfoxideHCID 1049PyridineHCID 6344DichloromethaneHCID 8471TriethylamineHCID 24682Sulfur trioxideHCID 77499N-(2-Hydroxyethyl)phthalimide

Product 1

HCID 76201Phthalylglycine aldehyde

Sources & evidence

ORD record
ord-500b3566fe2441de8dbbd6b2ba40a6a5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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