Diethyl Ether → 1-Benzyl-4-(2-fluorobenzyl)piperidin-4-ol

HRID 2157934Notes

Reaction equation

HRID 2157934 reaction equation
[CH2:10]([c:11]1[cH:12][cH:13][cH:14][cH:15][cH:16]1)[N:17]1[CH2:18][CH2:19][C:20](=[O:23])[CH2:21][CH2:22]1.[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:24][CH2:25][O:26][CH2:27][CH3:28].[CH3:34][CH2:35][O:36][CH2:37][CH3:38].[F:1][c:2]1[c:3]([CH2:4][Cl:5])[cH:6][cH:7][cH:8][cH:9]1>>[F:1][c:2]1[c:3]([CH2:4][C:20]2([OH:23])[CH2:19][CH2:18][N:17]([CH2:10][c:11]3[cH:12][cH:13][cH:14][cH:15][cH:16]3)[CH2:22][CH2:21]2)[cH:6][cH:7][cH:8][cH:9]1

Participants

5

Reactant 4

HCID 3283Diethyl Ether2×HCID 8028TetrahydrofuranHCID 9580Benzene, 1-(chloromethyl)-2-fluoro-HCID 192201-Benzyl-4-piperidone

Product 1

HCID 127332241-Benzyl-4-(2-fluorobenzyl)piperidin-4-ol

Sources & evidence

ORD record
ord-7840a8de485f4a2a92028b0e5609be95
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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