Hydrochloric Acid → 5-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-fluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide

HRID 2158164Notes

Reaction equation

HRID 2158164 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][C:8]1=[N:13][C:12]([CH2:14][F:15])([c:16]2[cH:17][c:18]([NH:22][C:23](=[O:24])[c:25]3[n:26][cH:27][c:28]([Br:31])[cH:29][cH:30]3)[cH:19][cH:20][cH:21]2)[CH2:11][O:10][CH2:9]1)([CH3:5])([CH3:6])[CH3:32].[CH3:34][OH:35].[ClH:33]>>[NH2:7][C:8]1=[N:13][C:12]([CH2:14][F:15])([c:16]2[cH:17][c:18]([NH:22][C:23](=[O:24])[c:25]3[n:26][cH:27][c:28]([Br:31])[cH:29][cH:30]3)[cH:19][cH:20][cH:21]2)[CH2:11][O:10][CH2:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 66665302(5-{3-[(5-Bromo-pyridine-2-carbonyl)-amino]-phenyl}-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

Product 1

HCID 581188175-Bromo-pyridine-2-carboxylic acid [3-(5-amino-3-fluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-phenyl]-amide

Sources & evidence

ORD record
ord-8f44a9cfee93448a9a285553f7a5cbf0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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