反应详情

In a round-bottomed flask equipped with a mechanical stirrer, 50 g of 4-(3-trifluoromethylphenyl)-4-piperidinol are charged to 377 ml of water and 514 ml of concentrated hydrochloric acid. The mixture is left to react at reflux for 5 hours and is then cooled to ambient temperature. A white solid precipitates. It is filtered off through a Büchner funnel and dried in an oven. 37 g of a white solid are isolated. M.p. 203-204° C.

1. customIn a round-bottomed flask equipped with a mechanical stirrer
2. waitThe mixture is left
3. customto react
4. temperatureat reflux for 5 hours
5. customA white solid precipitates
6. filtrationIt is filtered off through a Büchner funnel
7. customdried in an oven