HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 215865Generated: October 26, 2026
(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → [(R)-1-(4-tert-Butoxycarbonylamino-cyclohexylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/215865
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | (4-tert-Butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester | HCID 67022954 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | [(R)-1-(4-tert-Butoxycarbonylamino-cyclohexylcarbamoyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester | HCID 67023870 | — |
Reaction Steps
(4-tert-Butoxycarbonylamino-cyclohexyl)-carbamic acid phenyl ester (1 eq.) and (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester (1 eq.) are dissolved in NMP and heated at 100° C. for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08193164B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-1a3ac3933fbe4d898201fb0cdc4a414a |
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| Source note | uspto-grants-2012_06 |
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