反应详情

温度

65 °C

The title compound can be prepared by dissolving N-{(1S,2R,3S,4R)-4-[6-(2,2-diphenylethylamino)-2-(4-nitro-pyrazol-1-yl)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-2-hydroxy-acetamide (Intermediate QD) in methanol and adding a 2:1 by mass mixture of activated carbon and iron (III) chloride (40 mol % with respect to the substrate), followed by a large excess (100-fold with respect to the substrate) of hydrazine monohydrate. The resulting mixture is stirred at 65° C. for 3 hours, then filtered, before being concentrated under reduced pressure. Trituration of the residue with petroleum ether and subsequent filtration would give the desired product as a colourless solid.

1. additionadding a 2:1
2. filtrationfiltered
3. concentrationbefore being concentrated under reduced pressure
4. filtrationTrituration of the residue with petroleum ether and subsequent filtration