HRID215889

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)NCC#Cc1nc(N[C@H](CO)Cc2ccccc2)c2ncn([C@@H]3C[C@H](NC(=O)CO)[C@@H](O)[C@H]3O)c2n1

HCID67022958

未命名化合物

PRODUCTS

生成物

结构：NCC#Cc1nc(N[C@H](CO)Cc2ccccc2)c2ncn([C@@H]3C[C@H](NC(=O)CO)[C@@H](O)[C@H]3O)c2n1

HCID67022977

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

{3-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(2-hydroxy-acetylamino)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-prop-2-ynyl}-carbamic acid tert-butyl ester (Intermediate XA) is dissolved in 1.25 M HCl in MeOH. After stirring at RT for 3 days, the solvent is removed in vacuo to yield the title compound. This is used in the next step without further purification.

WORKUP

后处理

customthe solvent is removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b903bfac3b924d269bf175cfeb10cfba
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08193164B2
来源说明: uspto-grants-2012_06

反应 SMILES

C(OC(=O)[NH:7][CH2:8][C:9]#[C:10][C:11]1[N:19]=[C:18]2[C:14]([N:15]=[CH:16][N:17]2[C@@H:20]2[CH2:24][C@H:23]([NH:25][C:26](=[O:29])[CH2:27][OH:28])[C@@H:22]([OH:30])[C@H:21]2[OH:31])=[C:13]([NH:32][C@H:33]([CH2:41][OH:42])[CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[N:12]=1)(C)(C)C>Cl.CO>[NH2:7][CH2:8][C:9]#[C:10][C:11]1[N:19]=[C:18]2[C:14]([N:15]=[CH:16][N:17]2[C@@H:20]2[CH2:24][C@H:23]([NH:25][C:26](=[O:29])[CH2:27][OH:28])[C@@H:22]([OH:30])[C@H:21]2[OH:31])=[C:13]([NH:32][C@H:33]([CH2:41][OH:42])[CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[N:12]=1