Acetonitrile → HCID 25120994, compound

HRID 215902Notes

Reaction equation

HRID 215902 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C@H:12]([CH3:31])[C:13]([N:15]1[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][C:24]([S:27]([NH2:30])(=[O:29])=[O:28])=[CH:23][CH:22]=3)[CH2:17][CH2:16]1)=[O:14])[CH2:7][CH2:6][CH2:5]2.C(N(CC)CC)C.Cl[C:40]([O:42][CH3:43])=[O:41].C(#N)C>O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([C@H:12]([CH3:31])[C:13]([N:15]1[CH2:16][CH2:17][N:18]([C:21]3[CH:26]=[CH:25][C:24]([S:27]([NH:30][C:40](=[O:41])[O:42][CH3:43])(=[O:28])=[O:29])=[CH:23][CH:22]=3)[CH2:19][CH2:20]1)=[O:14])[CH2:7][CH2:6][CH2:5]2

Participants

6

Reactant 4

HCID 6342Acetonitrile2×HCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 59850051HCID 59850051, compound

Product 1

HCID 25120994HCID 25120994, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Synthesized according to General Procedure 1. The reaction was set-up with 0.07 mmol of (R)-4-(4-(2-(6-fluoro-3,4-dihydroquinolin-1(2H)-yl)propanoyl)piperazin-1-yl)benzene sulfonamide, 0.18 mmol of triethyl amine, 0.11 mmol of methyl chloroformate and 0.75 mL of acetonitrile. LC/MS (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)), m/z: M+1 obs=505.3; tR=2.28 min.

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-d9a5de7031094cabb97b85f9b5a6da8a
Source dataset
uspto-grants-2012_06
Patent number
US08193194B2

Reaction notes

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