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Sodium cyanoborohydride → N2-(3-(Diethylamino)propyl)-N4-(1-((1-methyl-1H-indol-7-yl)methyl)piperidin-4-yl)quinazoline-2,4-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 1-methyl-1H-indole-7-carbaldehyde | HCID 11040979 | — |
| 反応物 | N2-(3-(diethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine | HCID 67027548 | — |
| 触媒 | Zincchloride | HCID 3007855 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N2-(3-(Diethylamino)propyl)-N4-(1-((1-methyl-1H-indol-7-yl)methyl)piperidin-4-yl)quinazoline-2,4-diamine | HCID 58006186 | — |
反応手順
A solution of N2-(3-(diethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine (56 mg, 0.157 mmol), 1-methyl-1H-indole-7-carbaldehyde (27 mg, 0.157 mmol), NaCNBH3 (10 mg, 0.160 mmol) and ZnCl2 (11 mg, 0.08 mmol) in MeOH (1 ml) was stirred at room temperature overnight to obtain the target compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08193203B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-d5c39c9a97fc4ad8b3cfeb04696a7abb |
| 出典メモ | uspto-grants-2012_06 |