HRID215926

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

HCID11040979

1-methyl-1H-indole-7-carbaldehyde

C10H9NO

HCID67027548

未命名化合物

PRODUCTS

生成物

结构：CCN(CC)CCCNc1nc(NC2CCN(Cc3cccc4ccn(C)c34)CC2)c2ccccc2n1

HCID58006186

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID3007855

Zinc chloride

Cl2Zn

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of N2-(3-(diethylamino)propyl)-N4-(piperidin-4-yl)quinazoline-2,4-diamine (56 mg, 0.157 mmol), 1-methyl-1H-indole-7-carbaldehyde (27 mg, 0.157 mmol), NaCNBH3 (10 mg, 0.160 mmol) and ZnCl2 (11 mg, 0.08 mmol) in MeOH (1 ml) was stirred at room temperature overnight to obtain the target compound.

WORKUP

后处理

customto obtain the target compound

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d5c39c9a97fc4ad8b3cfeb04696a7abb
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08193203B2
来源说明: uspto-grants-2012_06

反应 SMILES

[CH2:1]([N:3]([CH2:25][CH3:26])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[N:17]=[C:16]([NH:18][CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)[CH3:2].[CH3:27][N:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][C:35]=2[CH:37]=O)[CH:30]=[CH:29]1.[BH3-]C#N.[Na+]>CO.[Cl-].[Cl-].[Zn+2]>[CH2:25]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][NH:7][C:8]1[N:17]=[C:16]([NH:18][CH:19]2[CH2:24][CH2:23][N:22]([CH2:37][C:35]3[CH:34]=[CH:33][CH:32]=[C:31]4[C:36]=3[N:28]([CH3:27])[CH:29]=[CH:30]4)[CH2:21][CH2:20]2)[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)[CH3:26]