HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-1-propanol → 3-({4-[(1-{2-(Dimethylamino)-6-[2-(dimethylamino)ethoxy]benzyl}piperidin-4-yl)amino]-6,7-dimethoxyquinazolin-2-yl}amino)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | 2-Chloro-N-(1-(2-(dimethylamino)-6-(2-(dimethylamino)ethoxy)benzyl)piperidin-4-yl)-6,7-dimethoxyquinazolin-4-amine | HCID 58006199 | — |
| Product | 3-({4-[(1-{2-(Dimethylamino)-6-[2-(dimethylamino)ethoxy]benzyl}piperidin-4-yl)amino]-6,7-dimethoxyquinazolin-2-yl}amino)propan-1-ol | HCID 58006133 | — |
Reaction Steps
Following General Procedure D, Compound 75 (0.25 g, 0.10 mmol) and 3-amino-1-propanol (0.12 mL, 1.61 mmol) were converted into compound 207 as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193203B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-9e4039d97aef47febd46f9b91cdcdff9 |
| Source note | uspto-grants-2012_06 |