HRID215934

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9086

3-Aminopropanol

C3H9NO

结构：COc1cc2nc(Cl)nc(NC3CCN(Cc4c(OCCN(C)C)cccc4N(C)C)CC3)c2cc1OC

HCID58006199

未命名化合物

PRODUCTS

生成物

结构：COc1cc2nc(NCCCO)nc(NC3CCN(Cc4c(OCCN(C)C)cccc4N(C)C)CC3)c2cc1OC

HCID58006133

未命名化合物

PROCEDURE

实验过程

Following General Procedure D, Compound 75 (0.25 g, 0.10 mmol) and 3-amino-1-propanol (0.12 mL, 1.61 mmol) were converted into compound 207 as a yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9e4039d97aef47febd46f9b91cdcdff9
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08193203B2
来源说明: uspto-grants-2012_06

反应 SMILES

Cl[C:2]1[N:11]=[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=3[N:32]([CH3:34])[CH3:33])[CH2:15][CH2:14]2)[C:9]2[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=2)[N:3]=1.[NH2:39][CH2:40][CH2:41][CH2:42][OH:43]>>[CH3:33][N:32]([CH3:34])[C:21]1[CH:22]=[CH:23][CH:24]=[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])[C:20]=1[CH2:19][N:16]1[CH2:17][CH2:18][CH:13]([NH:12][C:10]2[C:9]3[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=3)[N:3]=[C:2]([NH:39][CH2:40][CH2:41][CH2:42][OH:43])[N:11]=2)[CH2:14][CH2:15]1