3-Amino-1-propanol → 3-({4-[(1-{2-(Dimethylamino)-6-[2-(dimethylamino)ethoxy]benzyl}piperidin-4-yl)amino]-6,7-dimethoxyquinazolin-2-yl}amino)propan-1-ol

HRID 215934Notes

Reaction equation

HRID 215934 reaction equation
Cl[C:2]1[N:11]=[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=3[N:32]([CH3:34])[CH3:33])[CH2:15][CH2:14]2)[C:9]2[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=2)[N:3]=1.[NH2:39][CH2:40][CH2:41][CH2:42][OH:43]>>[CH3:33][N:32]([CH3:34])[C:21]1[CH:22]=[CH:23][CH:24]=[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])[C:20]=1[CH2:19][N:16]1[CH2:17][CH2:18][CH:13]([NH:12][C:10]2[C:9]3[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=3)[N:3]=[C:2]([NH:39][CH2:40][CH2:41][CH2:42][OH:43])[N:11]=2)[CH2:14][CH2:15]1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 580061992-Chloro-N-(1-(2-(dimethylamino)-6-(2-(dimethylamino)ethoxy)benzyl)piperidin-4-yl)-6,7-dimethoxyquinazolin-4-amine

Product 1

HCID 580061333-({4-[(1-{2-(Dimethylamino)-6-[2-(dimethylamino)ethoxy]benzyl}piperidin-4-yl)amino]-6,7-dimethoxyquinazolin-2-yl}amino)propan-1-ol

Procedure

Following General Procedure D, Compound 75 (0.25 g, 0.10 mmol) and 3-amino-1-propanol (0.12 mL, 1.61 mmol) were converted into compound 207 as a yellow oil.

Sources & evidence

ORD record
ord-9e4039d97aef47febd46f9b91cdcdff9
Source dataset
uspto-grants-2012_06
Patent number
US08193203B2

Reaction notes

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