Dichloromethane → 3-[(4-Methylsulfonylphenyl)methyl]-8-[(4-phenylpyrrolidin-3-yl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione

HRID 2159342Notes

Reaction equation

HRID 2159342 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([CH2:19][N:20]2[CH2:21][CH2:22][C:23]3([C:24](=[O:40])[N:25]([CH2:29][c:30]4[cH:31][cH:32][c:33]([S:36](=[O:37])(=[O:38])[CH3:39])[cH:34][cH:35]4)[C:26](=[O:28])[NH:27]3)[CH2:41][CH2:42]2)[CH:11]([c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:50][CH2:51][Cl:52].[F:43][C:44]([F:45])([F:46])[C:47]([OH:48])=[O:49]>>[NH:8]1[CH2:9][CH:10]([CH2:19][N:20]2[CH2:21][CH2:22][C:23]3([C:24](=[O:40])[N:25]([CH2:29][c:30]4[cH:31][cH:32][c:33]([S:36](=[O:37])(=[O:38])[CH3:39])[cH:34][cH:35]4)[C:26](=[O:28])[NH:27]3)[CH2:41][CH2:42]2)[CH:11]([c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[CH2:12]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 73034699Tert-butyl 3-[[3-[(4-methylsulfonylphenyl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl]methyl]-4-phenylpyrrolidine-1-carboxylate

Product 1

HCID 686251773-[(4-Methylsulfonylphenyl)methyl]-8-[(4-phenylpyrrolidin-3-yl)methyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione

Sources & evidence

ORD record
ord-6ace4d69bdaf48d381f632a3db1a4900
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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