HRID215937

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID276

Carbamic acid, ion(1-)

CH2NO2-

2 次

HCID6422

未命名化合物

HCID10679125

1-Boc-3-(Aminomethyl)azetidine

C9H18N2O2

结构：COc1cc2nc(Cl)nc(NC3CCN(Cc4c(OCCN(C)C)cccc4N(C)C)CC3)c2cc1OC

HCID58006199

未命名化合物

PRODUCTS

生成物

结构：COc1cc2nc(NCC3CNC3)nc(NC3CCN(Cc4c(OCCN(C)C)cccc4N(C)C)CC3)c2cc1OC

HCID58006259

未命名化合物

PROCEDURE

实验过程

Following General Procedure D, Compound 75 (100 mg, 0.18 mmol) and tert-butyl 3-(aminomethyl)azetidine-1-carboxylate (62 mg, 0.31 mmol) were converted into the carbamate product. The crude carbamate product was treated with CF3CO2H and purified using neutral alumina prep TLC, eluting with 5% NH3-MeOH and 95% CH2Cl2 to isolate the title compound.

WORKUP

后处理

custompurified
washeluting with 5% NH3-MeOH and 95% CH2Cl2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-05b85d18fbf446a1897f7fbc1dc6c43f
来源数据集: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08193203B2
来源说明: uspto-grants-2012_06

反应 SMILES

Cl[C:2]1[N:11]=[C:10]([NH:12][CH:13]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]3[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:24][CH:23]=[CH:22][C:21]=3[N:32]([CH3:34])[CH3:33])[CH2:15][CH2:14]2)[C:9]2[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=2)[N:3]=1.[NH2:39][CH2:40][CH:41]1[CH2:44][N:43](C(OC(C)(C)C)=O)[CH2:42]1.C(=O)([O-])N.C(C(O)=O)(F)(F)F>>[NH:43]1[CH2:44][CH:41]([CH2:40][NH:39][C:2]2[N:11]=[C:10]([NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][C:20]4[C:25]([O:26][CH2:27][CH2:28][N:29]([CH3:30])[CH3:31])=[CH:24][CH:23]=[CH:22][C:21]=4[N:32]([CH3:33])[CH3:34])[CH2:15][CH2:14]3)[C:9]3[C:4](=[CH:5][C:6]([O:37][CH3:38])=[C:7]([O:35][CH3:36])[CH:8]=3)[N:3]=2)[CH2:42]1