Dichloromethane → N-(4,4-Dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-(4-fluoro-benzylamino)-benzamide

HRID 2159383Notes

Reaction equation

HRID 2159383 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([NH:20][C:21]([c:22]3[c:23]([NH:28][CH2:29][c:30]4[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]4)[cH:24][cH:25][cH:26][cH:27]3)=[O:37])[cH:13][cH:14][c:15]2[C:16]([CH3:18])([CH3:19])[CH2:17]1)([CH3:5])([CH3:6])[CH3:7].[Cl:45][CH2:46][Cl:47].[F:38][C:39]([F:40])([F:41])[C:42]([OH:43])=[O:44]>>[NH:8]1[CH2:9][c:10]2[cH:11][c:12]([NH:20][C:21]([c:22]3[c:23]([NH:28][CH2:29][c:30]4[cH:31][cH:32][c:33]([F:36])[cH:34][cH:35]4)[cH:24][cH:25][cH:26][cH:27]3)=[O:37])[cH:13][cH:14][c:15]2[C:16]([CH3:18])([CH3:19])[CH2:17]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 695108657-[2-(4-Fluoro-benzylamino)-benzoylamino]-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Product 1

HCID 59017467N-(4,4-Dimethyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-2-(4-fluoro-benzylamino)-benzamide

Sources & evidence

ORD record
ord-6cd2245f82dc49a4a1de72b521e9520c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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