Triethylamine → 4-(5-fluoro-6-(3-fluoroazetidine-1-carbonyl)pyridin-3-yloxy)-2,2-dimethyl-N-(1-methyl-1H-pyrazol-3-yl)-2,3-dihydrobenzofuran-6-carboxamide

HRID 2159404Notes

Reaction equation

HRID 2159404 reaction equation
[CH3:37][CH2:38][N:39]([CH2:40][CH3:41])[CH2:42][CH3:43].[F:1][c:2]1[cH:3][c:4]([O:15][c:16]2[cH:17][c:18]([C:27](=[O:28])[OH:29])[cH:19][c:20]3[c:21]2[CH2:22][C:23]([CH3:25])([CH3:26])[O:24]3)[cH:5][n:6][c:7]1[C:8](=[O:9])[N:10]1[CH2:11][CH:12]([F:14])[CH2:13]1.[NH2:30][c:31]1[n:32][n:33]([CH3:36])[cH:34][cH:35]1.[P-:44]([F:45])([F:46])([F:47])([F:48])([F:49])[F:50].[n:51]1([O:52][C:53]([N:54]([CH3:55])[CH3:56])=[N+:57]([CH3:58])[CH3:59])[c:60]2[n:61][cH:62][cH:63][cH:64][c:65]2[n:66][n:67]1>>[F:1][c:2]1[cH:3][c:4]([O:15][c:16]2[cH:17][c:18]([C:27](=[O:29])[NH:30][c:31]3[n:32][n:33]([CH3:36])[cH:34][cH:35]3)[cH:19][c:20]3[c:21]2[CH2:22][C:23]([CH3:25])([CH3:26])[O:24]3)[cH:5][n:6][c:7]1[C:8](=[O:9])[N:10]1[CH2:11][CH:12]([F:14])[CH2:13]1

Participants

6

Reactant 5

HCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 1372541-Methyl-3-aminopyrazoleHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 595603264-(5-Fluoro-6-(3-fluoroazetidine-1-carbonyl)pyridin-3-yloxy)-2,2-dimethyl-2,3-dihydrobenzofuran-6-carboxylic acid

Product 1

HCID 251063754-(5-fluoro-6-(3-fluoroazetidine-1-carbonyl)pyridin-3-yloxy)-2,2-dimethyl-N-(1-methyl-1H-pyrazol-3-yl)-2,3-dihydrobenzofuran-6-carboxamide

Sources & evidence

ORD record
ord-2ea36d6bc046463e9eb2fe40d093f619
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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