反应详情

Prepared from ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate and lithium amide as described in Example 18. After evaporation of excess ammonia, the residue is treated with ice water. The insoluble material is filtered and washed with water, then recrystallized from ethyl acetate-hexane. Yield 78%; mp 151°-154° C.

1. customAfter evaporation of excess ammonia
2. additionthe residue is treated with ice water
3. filtrationThe insoluble material is filtered
4. washwashed with water
5. customrecrystallized from ethyl acetate-hexane