HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium amide → 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium amide | HCID 24532 | — |
| Reactant | ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate | HCID 15294535 | — |
| Product | 1-Methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxamide | HCID 15294532 | 78% |
Reaction Steps
Prepared from ethyl 1-methyl-3-[(1-methylethyl)thio]-5-(phenylmethoxy)-1H-indole-2-carboxylate and lithium amide as described in Example 18. After evaporation of excess ammonia, the residue is treated with ice water. The insoluble material is filtered and washed with water, then recrystallized from ethyl acetate-hexane. Yield 78%; mp 151°-154° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424329 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-a14145a8404a40248665186c7668a3e0 |
| Source note | uspto-grants-1995_06 |