Ethyl bromoacetate → Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

HRID 215964Notes

Reaction equation

HRID 215964 reaction equation
[Br:1][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1>>[BrH:1].[CH2:6]([O:5][C:3](=[O:4])[CH2:2][N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]1=[NH:8])[CH3:7]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 104392-Aminopyridine

Product 1

HCID 68699194Ethyl 2-(2-iminopyridin-1(2H)-yl)acetate hydrobromide

Procedure

To 39 mL (0.35 mol) of ethyl bromoacetate is added 9.4 g (0.1 mol) of 2-aminopyridine portionwise at 0° C. The resulting mixture is allowed to warm to room temperature and stirred at this temperature for 30 minutes. The precipitate is collected and washed with hexane to give the desired compound as light tan solid.

Workup

  1. customThe precipitate is collected
  2. washwashed with hexane

Sources & evidence

ORD record
ord-139322c54df1428e9f9697ab542f9be2
Source dataset
uspto-grants-2012_06
Patent number
US08193214B2

Reaction notes

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