Phosphorus oxychloride → 1-Chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

HRID 2159723Notes

Reaction equation

HRID 2159723 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6](-[c:16]3[cH:17][c:18]([F:22])[cH:19][cH:20][cH:21]3)[c:7]([C:14]#[N:15])[nH:8][c:9](=[O:13])[c:10]2[cH:11][cH:12]1.[P:23]([Cl:24])([Cl:25])([Cl:26])=[O:27]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6](-[c:16]3[cH:17][c:18]([F:22])[cH:19][cH:20][cH:21]3)[c:7]([C:14]#[N:15])[n:8][c:9]([Cl:25])[c:10]2[cH:11][cH:12]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 119954236-Methoxy-1-oxo-4-(3-fluorophenyl)-1,2-dihydroisoquinoline-3-carbonitrile

Product 1

HCID 112438971-Chloro-4-(3-fluorophenyl)-6-methoxyisoquinoline-3-carbonitrile

Sources & evidence

ORD record
ord-d5c86a6c44694e2594f2bc6bbf4164dd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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