HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 216022Generated: October 25, 2026
Triethylamine → 1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide
https://huagongshe.com/reaction/216022
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine | HCID 11106092 | — |
| Reactant | N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide | HCID 67036908 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N-(3-(4-fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide | HCID 44482390 | — |
Reaction Steps
N-(3-(4-Fluorophenoxy)phenyl)-4-methylpiperidine-4-carboxamide from step B (50 mg, 0.13 mmol), 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine from step C (19 mg, 0.1 mmol), and triethylamine (0.04 mL, 0.3 mmol) were combined in isopropanol (1 mL) and heated at 130° C. for 30 minutes under microwave conditions. The product was isolated by prep HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08193202B2 |
|---|
| Source dataset | uspto-grants-2012_06 |
|---|
| ORD ID | ord-bc079b1fb60a4c609e7c6b03dc4e4d03 |
|---|
| Source note | uspto-grants-2012_06 |
|---|
