Dimethylformamide → tert-butyl 2-[4-(2-methylimidazol-1-yl)anilino]-4-(oxolan-2-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

HRID 2160221Notes

Reaction equation

HRID 2160221 reaction equation
[CH3:1][c:2]1[n:3](-[c:7]2[cH:8][cH:9][c:10]([NH:13][c:14]3[n:15][c:16]([O:31][S:32]([C:33]([F:34])([F:35])[F:36])(=[O:37])=[O:38])[c:17]4[c:18]([n:19]3)[CH2:20][CH2:21][N:22]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:23]4)[cH:11][cH:12]2)[cH:4][cH:5][n:6]1.[O:39]1[CH:40]([CH2:44][NH2:45])[CH2:41][CH2:42][CH2:43]1.[O:46]=[CH:47][N:48]([CH3:49])[CH3:50]>>[CH3:1][c:2]1[n:3](-[c:7]2[cH:8][cH:9][c:10]([NH:13][c:14]3[n:15][c:16]([NH:45][CH2:44][CH:40]4[O:39][CH2:43][CH2:42][CH2:41]4)[c:17]4[c:18]([n:19]3)[CH2:20][CH2:21][N:22]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:23]4)[cH:11][cH:12]2)[cH:4][cH:5][n:6]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 253298TetrahydrofurfurylamineHCID 59333780tert-Butyl 2-(4-(2-methyl-1H-imidazol-1-yl)phenylamino)-4-(trifluoromethylsulfonyloxy)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Product 1

HCID 67423223tert-butyl 2-[4-(2-methylimidazol-1-yl)anilino]-4-(oxolan-2-ylmethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate

Sources & evidence

ORD record
ord-a9f830f5435b436baa3e657366f6a6d5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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