Dichloromethane → Trifluoroacetic acid

HRID 2160380Notes

Reaction equation

HRID 2160380 reaction equation
[CH3:1][O:2][c:3]1[c:4]([O:45][CH2:46][CH2:47][O:48][CH3:49])[cH:5][c:6]2[c:7]([NH:28][c:29]3[cH:30][c:31]4[cH:32][n:33][n:34]([C:38]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])[c:35]4[cH:36][cH:37]3)[n:8][c:9](-[c:13]3[cH:14][c:15]([NH:19][C:20]([c:21]4[cH:22][n:23][cH:24][cH:25][cH:26]4)=[O:27])[cH:16][cH:17][cH:18]3)[n:10][c:11]2[cH:12]1.[Cl:57][CH2:58][Cl:59].[F:50][C:51]([C:52](=[O:53])[OH:54])([F:55])[F:56]>>[CH3:1][O:2][c:3]1[c:4]([O:45][CH2:46][CH2:47][O:48][CH3:49])[cH:5][c:6]2[c:7]([NH:28][c:29]3[cH:30][c:31]4[cH:32][n:33][nH:34][c:35]4[cH:36][cH:37]3)[n:8][c:9](-[c:13]3[cH:14][c:15]([NH:19][C:20]([c:21]4[cH:22][n:23][cH:24][cH:25][cH:26]4)=[O:27])[cH:16][cH:17][cH:18]3)[n:10][c:11]2[cH:12]1.[F:50][C:51]([C:52](=[O:53])[OH:54])([F:55])[F:56]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59361913tert-butyl 5-(7-methoxy-6-(2-methoxyethoxy)-2-(3-(nicotinamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 25012085N-[3-[4-(1H-indazol-5-ylamino)-7-methoxy-6-(2-methoxyethoxy)quinazolin-2-yl]phenyl]pyridine-3-carboxamide

Sources & evidence

ORD record
ord-862e2a89f0474588bea05af498265d61
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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