Hydrochloric Acid → HCID 63121615, compound

HRID 216043Notes

Reaction equation

HRID 216043 reaction equation
[CH3:1][C:2]1([C:15](=[O:27])[NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([S:23](=[O:26])(=[O:25])[NH2:24])[CH:18]=2)[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4][CH2:3]1.Cl>CO>[CH3:1][C:2]1([C:15]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([S:23](=[O:26])(=[O:25])[NH2:24])[CH:18]=2)=[O:27])[CH2:3][CH2:4][NH:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67036917Tert-butyl 4-methyl-4-(3-sulfamoylphenylcarbamoyl)piperidine-1-carboxylate

Product 1

HCID 63121615HCID 63121615, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

tert-Butyl 4-methyl-4-(3-sulfamoylphenylcarbamoyl)piperidine-1-carboxylate from step A (39 mg, 0.098 mmol) was treated with HCl (4.0 N in dioxane, 98 μL, 0.39 mmol) in methanol (1.0 mL) at 50° C. for 45 minutes. The mixture was concentrated to give the title compound as the hydrochloride salt in quantitative yield. MS (ES+) [M+H]+=298.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-ebc86fa4b960460b8b00e6bc8eaa1a23
Source dataset
uspto-grants-2012_06
Patent number
US08193202B2

Reaction notes

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