Hydrochloric Acid → HCID 178431740, compound

HRID 216046Notes

Reaction equation

HRID 216046 reaction equation
[NH:1]1[C:5]([C:6]2[CH:7]=[C:8]([NH:12][C:13]([C:15]3([CH3:28])[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[O:14])[CH:9]=[CH:10][CH:11]=2)=[N:4][N:3]=[N:2]1.Cl>CO>[NH:4]1[C:5]([C:6]2[CH:7]=[C:8]([NH:12][C:13]([C:15]3([CH3:28])[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[O:14])[CH:9]=[CH:10][CH:11]=2)=[N:1][N:2]=[N:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178451883tert-butyl 4-(3-(1H-tetrazol-5-yl)phenylcarbamoyl)-4-methylpiperidine-1-carboxylate

Product 1

HCID 178431740HCID 178431740, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

tert-Butyl 4-(3-(1H-tetrazol-5-yl)phenylcarbamoyl)-4-methylpiperidine-1-carboxylate from step A (0.11 g, 0.29 mmol) was treated with HCl (4.0 N in dioxane, 0.36 mL, 1.45 mmol) in methanol (2.0 mL) and heated at 50° C. for 30 minutes. The mixture was concentrated to give the title compound as the hydrochloride salt in quantitative yield. MS (ES+) [M+H]+=287.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-7cc9155d91a143ce8bcd13d651828b7a
Source dataset
uspto-grants-2012_06
Patent number
US08193202B2

Reaction notes

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