Carbonate Ion → N-{5-[({2-[(2,3-Difluorobenzyl)thio]-6-methoxypyrimidin-4-yl)amino)sulfonyl]-4-methyl-1,3-thiazol-2-yl]acetamide
Reaction equation
[C:49](=[O:50])([O-:51])[O-:52].[CH:15]1([P:16]([CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[c:23]2[cH:24][cH:25][cH:26][cH:27][c:28]2-[c:29]2[c:30]([CH:31]([CH3:32])[CH3:33])[cH:34][c:35]([CH:36]([CH3:37])[CH3:38])[cH:39][c:40]2[CH:41]([CH3:42])[CH3:43])[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]1.[Cl:55][c:56]1[n:57][c:58]([S:64][CH2:65][c:66]2[c:67]([F:73])[c:68]([F:72])[cH:69][cH:70][cH:71]2)[n:59][c:60]([O:62][CH3:63])[cH:61]1.[Cs+:53].[Cs+:54].[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[c:6]([CH3:14])[n:7][c:8]([NH:10][C:11]([CH3:12])=[O:13])[s:9]1.[O:100]=[C:101]([CH:102]=[CH:103][c:104]1[cH:105][cH:106][cH:107][cH:108][cH:109]1)[CH:110]=[CH:111][c:112]1[cH:113][cH:114][cH:115][cH:116][cH:117]1.[O:118]=[C:119]([CH:120]=[CH:121][c:122]1[cH:123][cH:124][cH:125][cH:126][cH:127]1)[CH:128]=[CH:129][c:130]1[cH:131][cH:132][cH:133][cH:134][cH:135]1.[O:74]1[CH2:75][CH2:76][O:77][CH2:78][CH2:79]1.[O:82]=[C:83]([CH:84]=[CH:85][c:86]1[cH:87][cH:88][cH:89][cH:90][cH:91]1)[CH:92]=[CH:93][c:94]1[cH:95][cH:96][cH:97][cH:98][cH:99]1.[Pd:80].[Pd:81]>>[NH:1]([S:2](=[O:3])(=[O:4])[c:5]1[c:6]([CH3:14])[n:7][c:8]([NH:10][C:11]([CH3:12])=[O:13])[s:9]1)[c:56]1[n:57][c:58]([S:64][CH2:65][c:66]2[c:67]([F:73])[c:68]([F:72])[cH:69][cH:70][cH:71]2)[n:59][c:60]([O:62][CH3:63])[cH:61]1Participants
9
Reactant 8
HCID 19660Carbonate Ion
HCID 23938Palladium2×
HCID 312751,4-Dioxane
HCID 95417Dibenzylidene acetone3×
HCID 104967Cesium cation2×
HCID 3244062N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide
HCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl
HCID 866198774-Chloro-2-([(2,3-difluorophenyl)methyl]thio]-6-methoxypyrimidineProduct 1
Sources & evidence
- ORD record
- ord-eaa2cc6e61f647de9af0c3f917345aad
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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