Hydrochloric Acid → HCID 67036770, compound

HRID 216083Notes

Reaction equation

HRID 216083 reaction equation
[CH2:1]([O:8][C:9]1([C:22](=[O:36])[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31](=[O:35])[N:32]([CH3:34])[CH3:33])[CH:25]=2)[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO>[CH3:33][N:32]([CH3:34])[C:31](=[O:35])[O:30][C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([NH:23][C:22]([C:9]2([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:36])[CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68989159HCID 68989159, compound

Product 1

HCID 67036770HCID 67036770, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of tert-butyl 4-(benzyloxy)-4-(3-(dimethylcarbamoyloxy)-phenylcarbamoyl)piperidine-1-carboxylate from step D (400 mg, 0.804 mmol) in methanol (4 mL) was added HCl (4 M solution in dioxane, 0.8 mL). The reaction was heated at 50° C. for 1 hour, and then concentrated under vacuum to provide the title compound as the hydrochloride salt. MS (ES+) [M+H]+=398.4.

Workup

  1. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-f00d4621f6834f35942a1db1c7c0e45c
Source dataset
uspto-grants-2012_06
Patent number
US08193202B2

Reaction notes

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