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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2160944Generated: October 30, 2026

Tetrahydrofuran → N-{5-[(2-Chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamide

https://huagongshe.com/reaction/2160944

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantTriethylamineHCID 8471—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
Reactant2,4-DichloropyrimidineHCID 77531—
ReactantN-(5-ethynyl-2-fluorophenyl)-2,2,2-trifluoroacetamideHCID 59511405—
ProductN-{5-[(2-Chloro-4-pyrimidinyl)ethynyl]-2-fluorophenyl}-2,2,2-trifluoroacetamideHCID 59511388—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (4/10)
ORD IDord-323a1fd09ec645b080cffd4214520b57
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (4/10)