反应详情

A mixture of (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(4-methoxy-phenyl)-ethyl]-amine (150 mg, 0.51 mmol, Intermediate (8) prepared as described in Example 2 step 1), quinoline-6-boronic acid [176 mg, 1.02 mmol, Intermediate (22)], Cs2CO3 (590 mg, 1.81 mmol) tetrakis(triphenylphosphine)palladium (0) (59 mg, 0.051 mmol), ethylene glycol dimethyl ether (4 mL) and water (1 mL) is placed in a microwave tube, sealed and evacuated and flushed with argon three times and irradiated in a microwave oven at 140° C. for 10 minutes. The reaction mixture is partitioned between EtOAc and water. The organic phase is separated, washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated. The residual solid is subjected to flash column chromatography on silica gel eluting with a mixture of EtOAc and heptane. The material is recrystallized from MeOH to afford [2-(4-methoxy-phenyl)-ethyl]-(2-methoxy-6-quinolin-6-yl-pyrimidin-4-yl)-amine [140 mg, 71%, Example 10(a)] LCMS: RT=5.97 minutes, MS: 387 (M+H). IC50=0.6 nM

1. customis placed in a microwave tube
2. customsealed
3. customevacuated
4. customflushed with argon three times
5. customirradiated in a microwave oven at 140° C. for 10 minutes
6. customThe reaction mixture is partitioned between EtOAc and water
7. customThe organic phase is separated
8. washwashed with saturated sodium bicarbonate solution
9. dry with materialdried over magnesium sulfate
10. customevaporated
11. additionThe residual solid is subjected to flash column chromatography on silica gel eluting with a mixture of EtOAc and heptane
12. customThe material is recrystallized from MeOH