反应详情

To a solution of the product of step B (13.40 g, 50.9 mmol) in dimethylformamide (35 mL) was added NaN3 (16.5 g, 255 mmol). The reaction was stirred at room temperature for 18 hours then at 60° C. for 2 hours, cooled to room temperature, diluted with water (400 mL) and extracted with ethyl acetate. The organic layer was washed with water (2×) then with brine and dried (Na2SO4). Evaporation under reduced pressure afforded 10.70 g (100%) of product as a tan oil.

1. waitat 60° C. for 2 hours
2. temperaturecooled to room temperature
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with water (2×)
5. dry with materialwith brine and dried (Na2SO4)
6. customEvaporation under reduced pressure