Triphenylphosphine → 2-(4-Chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-morpholine

HRID 2161429Notes

Reaction equation

HRID 2161429 reaction equation
[CH3:21][C:22]1([CH3:23])[C:24]([CH3:25])([CH3:26])[O:27][B:28]([c:29]2[cH:30][n:31][nH:32][cH:33]2)[O:34]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([c:14]3[cH:15][cH:16][c:17]([I:20])[cH:18][cH:19]3)[O:9][CH2:10][CH2:11][NH:12][CH2:13]2)[cH:6][cH:7]1.[Pd:35].[c:36]1([P:37]([c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[cH:50][cH:51][cH:52][cH:53][cH:54]1.[c:55]1([P:56]([c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[c:63]2[cH:64][cH:65][cH:66][cH:67][cH:68]2)[cH:69][cH:70][cH:71][cH:72][cH:73]1.[c:74]1([P:75]([c:76]2[cH:77][cH:78][cH:79][cH:80][cH:81]2)[c:82]2[cH:83][cH:84][cH:85][cH:86][cH:87]2)[cH:88][cH:89][cH:90][cH:91][cH:92]1.[c:93]1([P:94]([c:95]2[cH:96][cH:97][cH:98][cH:99][cH:100]2)[c:101]2[cH:102][cH:103][cH:104][cH:105][cH:106]2)[cH:107][cH:108][cH:109][cH:110][cH:111]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([c:14]3[cH:15][cH:16][c:17](-[c:29]4[cH:30][n:31][nH:32][cH:33]4)[cH:18][cH:19]3)[O:9][CH2:10][CH2:11][NH:12][CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 11776Triphenylphosphine4×HCID 23938PalladiumHCID 27740104-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 593319352-(4-Chlorophenyl)-2-(4-iodophenyl)morpholine

Product 1

HCID 114619212-(4-Chloro-phenyl)-2-[4-(1H-pyrazol-4-yl)-phenyl]-morpholine

Sources & evidence

ORD record
ord-bdbd861c97344f70bea130abff7d18fd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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